FUS

Aliases 
ALS6, FFUS1, HNRNPP2, POMP75, TLS
Chromosomal Locations 
16p11.2

This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and teh export of fully processed mRNA to the cytoplasm.

This protein belongs to the FET family of FET family of RNA-binding proteings which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing.

Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6.

Description 
fused in sarcoma 75 kDa DNA-pairing protein RNA-binding protein FUS fus-like protein fusion gene in myxoid lipsarcoma heterogeneous nuclear ribonucleoprotein P2 oncogene FUS oncogene TLS translocated in liposarcoma protein
Tests 
Amyotrophic Lateral Sclerosis (ALS)